Lloyd Christmas is a limo driver who's a few beers short of a six pack. His equally clueless roommate Harry Dunn is an operator for a mobile pet grooming service called "Mutt Cutts." One day, Lloyd picks up a wealthy customer, Mary Swanson, from the airport, and instantly falls in love with her. Little does Lloyd know that Mary is the victim of an elaborate kidnapping and extortion plot, and the trip to the airport was supposed to be the payoff to release her kidnapped husband. Lloyd grabs the briefcase, which really contains $5 million in cash, setting off a chain of events that see him and Harry going to Aspen, Colorado, and meeting nearly every seedy and shady character involved in the conspiracy. Their friendship is tested at every stop along the way. Will they make it to Aspen and live the high life, or face the wrath of the kidnappers and the FBI?